KAT8

Across TCGA patient cohorts, KAT8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT8-associated genes across cancer lineages are EGFR_pY1068, JNK2, and MSH2. Each is linked with KAT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT8-to-partner and partner-to-KAT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KAT8-low versus KAT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT8→partner) and Y-score (partner→KAT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.249	-3.169	.040	.018	3	1
UCEC	JNK2 →	+0.305	+3.009	.001	.019	3	1
UCEC	MSH2 →	-0.352	-3.160	.001	.019	3	1
UCEC	NF2 →	+0.336	+3.000	.001	.036	3	1
UCEC	p27_pT157 →	-0.070	-3.584	.012	.002	3	1
UCEC	Rab25 →	-0.482	-2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by KAT8 expression — UCEC

Explore this box plot interactively →