KAT8

Across TCGA cell cohorts, KAT8 mutation is significantly associated with the mutation status of many other genes, with 2,923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KAT8-associated genes across cancer lineages are PRKCH, KATNIP, and SLC25A13. Each is linked with KAT8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KAT8-to-partner and partner-to-KAT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKCH grouped by KAT8-low versus KAT8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT8→partner) and Y-score (partner→KAT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRKCH →	+5.053	+4.239	.007	.007	1	3
BLOOD_Leukemia	KATNIP →	+3.753	+5.347	<.001	<.001	1	3
BLOOD_Leukemia	SLC25A13 →	+4.560	+4.309	.007	.007	1	3
BLOOD_Leukemia	GLI2 →	+2.238	+4.044	.005	.005	1	3
LARGE_INTESTINE	GTSE1 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	VPS9D1 →	+3.007	+3.584	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,923 associations by consensus.

PRKCH by KAT8 expression — SKIN

Explore this box plot interactively →