KAT7

Across TCGA patient cohorts, KAT7 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT7-associated genes across cancer lineages are eIF4E, Notch1, and p62 Lck ligand. Each is linked with KAT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT7-to-partner and partner-to-KAT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KAT7-low versus KAT7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT7→partner) and Y-score (partner→KAT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.152	+2.598	.025	.005	3	2
UCEC	Notch1 →	+0.198	+2.179	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.383	+2.906	<.001	.001	3	2
UCEC	ATM →	-0.373	-2.115	.011	.017	3	2
UCEC	EGFR_pY1068 →	-0.279	-2.321	<.001	<.001	3	1
UCEC	eIF4G →	+0.238	+2.000	.018	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by KAT7 expression — UCEC

Explore this box plot interactively →