KAT6A

Across TCGA patient cohorts, KAT6A mutation is significantly associated with the RNA expression of many other genes, with 5,705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT6A-associated genes across cancer lineages are FAXDC2, NIPA2P5, and CTLA4. Each is linked with KAT6A in more than 3 cancer types. Because this analysis shows association rather than direction, both KAT6A-to-partner and partner-to-KAT6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAXDC2 grouped by KAT6A-low versus KAT6A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6A→partner) and Y-score (partner→KAT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FAXDC2 →	-1.150	-3.446	<.001	.005	3	4
LUSC	NIPA2P5 →	+0.106	+3.625	<.001	.003	3	3
SKCM	CTLA4 →	+0.933	+2.208	.002	<.001	3	3
UCEC	MSANTD3 →	+0.470	+1.802	<.001	<.001	3	3
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	3
UCEC	CENPM →	+0.484	+1.652	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,705 associations by consensus.

FAXDC2 by KAT6A expression — STAD

Explore this box plot interactively →