KAT6A

Across TCGA patient cohorts, KAT6A mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT6A-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and Chk1. Each is linked with KAT6A in more than 3 cancer types. Because this analysis shows association rather than direction, both KAT6A-to-partner and partner-to-KAT6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KAT6A-low versus KAT6A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6A→partner) and Y-score (partner→KAT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.996	+3.016	.001	.018	3	4
STAD	Cyclin-E2 →	+0.186	+2.190	.003	.033	3	3
COAD	Chk1 →	+0.224	+3.000	.013	.034	3	3
UCEC	Notch1 →	+0.164	+2.335	<.001	<.001	3	3
UCEC	ASNS →	+0.306	+1.222	.001	.029	3	3
UCEC	ATM →	-0.526	-2.794	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Caspase-7-cleavedD198 by KAT6A expression — COAD

Explore this box plot interactively →