KAT6A

Across TCGA cell cohorts, KAT6A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,737 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KAT6A-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with KAT6A in more than 16 cancer types. Because this analysis shows association rather than direction, both KAT6A-to-partner and partner-to-KAT6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by KAT6A-low versus KAT6A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6A→partner) and Y-score (partner→KAT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nucleotide-excision repair →	+0.137	+0.944	<.001	.006	3	17
OVARY	Heterochromatin formation →	+0.065	+0.908	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.068	+1.459	<.001	<.001	3	16
URINARY_TRACT	Regulation of heterochromatin organization →	+0.122	+1.075	.001	<.001	3	16
KIDNEY	Peptidyl-serine phosphorylation →	+0.088	+0.762	.002	.005	3	16
OVARY	Microtubule anchoring →	+0.093	+1.265	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,737 associations by consensus.

Regulation of nucleotide-excision repair by KAT6A expression — BONE

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