KAT6A

Across TCGA cell cohorts, KAT6A mutation is significantly associated with the RNA expression of many other genes, with 1,012 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KAT6A-associated genes across cancer lineages are TAC1, BBS7, and CD1B. Each is linked with KAT6A in more than 2 cancer types. Because this analysis shows association rather than direction, both KAT6A-to-partner and partner-to-KAT6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAC1 grouped by KAT6A-low versus KAT6A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6A→partner) and Y-score (partner→KAT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TAC1 →	+1.755	+4.209	<.001	.006	3	3
LARGE_INTESTINE	BBS7 →	+0.576	+2.523	<.001	.003	3	3
PANCREAS	CD1B →	+0.046	+4.754	.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	MAGEA9 →	+0.660	+4.209	.004	.006	3	2
OVARY	LYVE1 →	+0.034	+4.029	<.001	.009	3	2
SKIN	AGRP →	+0.142	+3.141	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,012 associations by consensus.

TAC1 by KAT6A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →