KAT2B

Across TCGA patient cohorts, KAT2B mutation is significantly associated with the RNA expression of many other genes, with 3,075 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT2B-associated genes across cancer lineages are SKA2, CDKN3, and ICMT. Each is linked with KAT2B in more than 3 cancer types. Because this analysis shows association rather than direction, both KAT2B-to-partner and partner-to-KAT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA2 grouped by KAT2B-low versus KAT2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT2B→partner) and Y-score (partner→KAT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA2 →	+0.442	+2.379	.003	<.001	3	4
UCEC	CDKN3 →	+0.751	+2.662	<.001	<.001	3	3
UCEC	ICMT →	+0.401	+3.385	<.001	<.001	3	3
UCEC	GOT1 →	+0.347	+2.163	.001	<.001	3	3
UCEC	CEP55 →	+0.542	+1.432	.004	.005	3	3
UCEC	SKA1 →	+0.703	+2.379	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,075 associations by consensus.

SKA2 by KAT2B expression — UCEC

Explore this box plot interactively →