KAT2B

Across TCGA patient cohorts, KAT2B mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT2B-associated genes across cancer lineages are EGFR_pY1068, 14-3-3_epsilon, and PCNA. Each is linked with KAT2B in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT2B-to-partner and partner-to-KAT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KAT2B-low versus KAT2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT2B→partner) and Y-score (partner→KAT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.248	-1.836	.001	.001	3	2
UCEC	14-3-3_epsilon →	+0.072	+1.353	.020	.015	3	2
UCEC	PCNA →	+0.250	+2.115	<.001	<.001	3	2
COAD	PDCD4 →	-0.659	-2.991	.002	.036	3	2
UCEC	PKC-b-II_pS660 →	-0.174	-1.137	.046	.041	3	2
UCEC	Shc_pY317 →	-0.133	-1.415	.005	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

EGFR_pY1068 by KAT2B expression — UCEC

Explore this box plot interactively →