KAT2A

Across TCGA pan-cancer cohorts, KAT2A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KAT2A data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KAT2A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KAT2A expression acts as an unfavorable survival marker.

LUAD, THCA, and DLBC are the cancer types where KAT2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.057	0.709	<.001	28	view →
THCA	OS	Median	All	0.940	0.993	<.001	15	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
BLCA	OS	Median	IV	0.120	0.599	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	OS	Median	All	0.082	0.653	.002	6	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KAT2A–LUAD (OS)

Open the LUAD breakdown →