KAT2A

Across TCGA pan-cancer cohorts, KAT2A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KAT2A data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KAT2A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KAT2A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where KAT2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.968	0.777	.042	6	view →
HNSC	DFS	Median	III,IV	0.298	0.858	.019	5	view →
LUAD	DFS	Median	III,IV	0.922	0.409	.024	5	view →
LSCC	OS	Tertile	All	0.877	0.696	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KAT2A–UCEC (OS)

Open the UCEC breakdown →