KAT2A

Across TCGA cell cohorts, KAT2A mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KAT2A-associated genes across cancer lineages are APOL5, OR2M5, and TEX55. Each is linked with KAT2A in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT2A-to-partner and partner-to-KAT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by KAT2A-low versus KAT2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT2A→partner) and Y-score (partner→KAT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.018	+4.060	<.001	.003	3	1
BLOOD_Leukemia	OR2M5 →	+0.013	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TEX55 →	+0.011	+4.060	.006	.003	3	1
BLOOD_Leukemia	NXNL1 →	+0.160	+4.567	<.001	.001	3	1
BLOOD_Leukemia	ZCCHC13 →	+0.018	+4.984	<.001	.002	3	1
BLOOD_Leukemia	OR6Y1 →	+0.011	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

APOL5 by KAT2A expression — BLOOD_Leukemia

Explore this box plot interactively →