KAT14

Across TCGA patient cohorts, KAT14 mutation is significantly associated with the RNA expression of many other genes, with 4,471 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT14-associated genes across cancer lineages are RPL17P50, CDRT15P2, and TXNL1. Each is linked with KAT14 in more than 3 cancer types. Because this analysis shows association rather than direction, both KAT14-to-partner and partner-to-KAT14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P50 grouped by KAT14-low versus KAT14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT14→partner) and Y-score (partner→KAT14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL17P50 →	+0.379	+2.436	.005	.001	3	4
CESC	CDRT15P2 →	+0.070	+4.342	<.001	.007	3	3
COAD	TXNL1 →	+0.426	+3.638	.004	.001	3	3
HNSC	EIF3JP1 →	+0.144	+3.654	.002	.009	3	3
UCEC	HAUS1 →	+0.482	+1.684	.002	.003	3	3
UCEC	DCK →	+0.586	+2.169	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,471 associations by consensus.

RPL17P50 by KAT14 expression — UCEC

Explore this box plot interactively →