KASH5

Across TCGA patient cohorts, KASH5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KASH5-associated genes across cancer lineages are ATM, Caspase-8, and XBP1. Each is linked with KASH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KASH5-to-partner and partner-to-KASH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KASH5-low versus KASH5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KASH5→partner) and Y-score (partner→KASH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.633	-2.991	.001	.036	3	2
UCEC	Caspase-8 →	-0.237	-3.459	.036	.005	3	1
COAD	XBP1 →	+0.272	+3.008	.005	.019	3	1
UCEC	Rab11 →	-0.129	-2.980	.048	.036	2	1
COAD	PKC-a_pS657 →	-0.432	-2.991	.006	.036	2	1
COAD	Caspase-7-cleavedD198 →	+1.120	+3.008	.006	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by KASH5 expression — COAD

Explore this box plot interactively →