KARS1

Across TCGA pan-cancer cohorts, KARS1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KARS1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KARS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KARS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

LUAD, PRAD, and BLCA are the cancer types where KARS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.158	0.663	.008	12	view →
PRAD	DFS	Median	All	0.099	0.886	<.001	6	view →
BLCA	OS	Median	IV	0.506	0.284	.003	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KARS1–LUAD (OS)

Open the LUAD breakdown →