KARS1

Across TCGA patient cohorts, KARS1 protein abundance is significantly associated with the RNA expression of many other genes, with 21,391 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KARS1-associated genes across cancer lineages are NIP7, PSMD7, and RFWD3. Each is linked with KARS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both KARS1-to-partner and partner-to-KARS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KARS1 versus NIP7 in BRCA, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KARS1→partner) and Y-score (partner→KARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NIP7 →	+0.692	+0.380	<.001	<.001	3	9
OV	PSMD7 →	+0.756	+0.409	<.001	<.001	3	8
OV	RFWD3 →	+0.774	+0.404	<.001	<.001	3	8
UCEC	APRT →	+1.455	+0.239	.001	<.001	3	8
UCEC	EMC8 →	+0.716	+0.262	<.001	<.001	3	7
UCEC	TMEM208 →	+1.257	+0.290	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,391 associations by consensus.

KARS1 vs NIP7 — BRCA

Explore this scatter interactively →