KARS1

Across TCGA patient cohorts, KARS1 mutation is significantly associated with the RNA expression of many other genes, with 3,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KARS1-associated genes across cancer lineages are OR2M7, SNORD90, and CIRBP-AS1. Each is linked with KARS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KARS1-to-partner and partner-to-KARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M7 grouped by KARS1-low versus KARS1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KARS1→partner) and Y-score (partner→KARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR2M7 →	+0.041	+4.463	<.001	.003	3	3
UCEC	SNORD90 →	+0.225	+1.740	<.001	.009	3	3
UCEC	CIRBP-AS1 →	+0.522	+2.071	<.001	.004	3	2
READ	TEX36 →	+0.066	+5.219	<.001	.006	3	2
READ	LINC02629 →	+0.145	+5.653	<.001	.003	3	2
KIRP	LINC02743 →	+0.052	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,165 associations by consensus.

OR2M7 by KARS1 expression — BLCA

Explore this box plot interactively →