KARS1

Across TCGA cell cohorts, KARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,965 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KARS1-associated GO terms across cancer lineages are DNA replication initiation, Nucleolar large rRNA transcription by RNA polymerase I, and Double-strand break repair via break-induced replication. Each is linked with KARS1 in more than 16 cancer types. Because this analysis shows association rather than direction, both KARS1-to-partner and partner-to-KARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by KARS1-low versus KARS1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KARS1→partner) and Y-score (partner→KARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA replication initiation →	+0.164	+0.693	<.001	<.001	3	17
LUNG_SCLC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.150	+0.810	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.260	+0.971	<.001	<.001	3	16
LUNG_NSCLC_LUSC	'de novo' UMP biosynthetic process →	+0.181	+0.934	.002	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Ribosomal small subunit biogenesis →	+0.106	+0.710	.002	.001	3	16
LUNG_SCLC	Transcription initiation at RNA polymerase I promoter →	+0.118	+0.769	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,965 associations by consensus.

DNA replication initiation by KARS1 expression — SOFT_TISSUE

Explore this box plot interactively →