KARS1

Across TCGA cell cohorts, KARS1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KARS1-associated genes across cancer lineages are DTHD1, GPR101, and BAAT. Each is linked with KARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KARS1-to-partner and partner-to-KARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DTHD1 grouped by KARS1-low versus KARS1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KARS1→partner) and Y-score (partner→KARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DTHD1 →	+0.034	+3.523	<.001	.008	3	2
LUNG_NSCLC_LUAD	GPR101 →	+0.018	+4.887	<.001	.009	3	2
LARGE_INTESTINE	BAAT →	+0.589	+3.273	<.001	.006	3	1
LARGE_INTESTINE	OR4F21 →	+0.154	+2.556	<.001	.006	3	1
CNS	PNMA6F →	+0.006	+4.981	.007	.008	3	1
LUNG_SCLC	DMRTC2 →	+0.125	+3.523	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DTHD1 by KARS1 expression — LUNG_SCLC

Explore this box plot interactively →