KANSL1

Across TCGA patient cohorts, KANSL1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANSL1-associated genes across cancer lineages are EGFR_pY1068, PCNA, and eEF2. Each is linked with KANSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KANSL1-to-partner and partner-to-KANSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KANSL1-low versus KANSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANSL1→partner) and Y-score (partner→KANSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.192	-1.343	.004	.002	3	3
UCEC	PCNA →	+0.166	+1.662	.003	.009	3	3
UCEC	eEF2 →	+0.239	+2.247	.012	.001	3	2
COAD	mTOR_pS2448 →	-0.210	-3.157	.002	.018	3	2
COAD	RAD51 →	+0.192	+3.584	.001	.002	2	3
COAD	TIGAR →	+0.360	+2.321	.020	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

EGFR_pY1068 by KANSL1 expression — UCEC

Explore this box plot interactively →