KANK4

Across TCGA pan-cancer cohorts, KANK4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KANK4 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KANK4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KANK4 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where KANK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.474	0.820	<.001	56	view →
HNSC	OS	Tertile	IV	0.512	0.939	.001	56	view →
PDAC	OS	Tertile	All	0.268	0.530	<.001	39	view →
GBM	OS	Median	All	0.202	0.867	.010	6	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →
CCRCC	DFS	Median	All	0.732	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KANK4–LSCC (DFS)

Open the LSCC breakdown →