KANK4

Across TCGA patient cohorts, KANK4 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANK4-associated genes across cancer lineages are ATM, Cyclin-B1, and PKC-delta_pS664. Each is linked with KANK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KANK4-to-partner and partner-to-KANK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KANK4-low versus KANK4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANK4→partner) and Y-score (partner→KANK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.617	-3.000	.002	.034	3	4
UCEC	Cyclin-B1 →	+0.774	+2.485	<.001	<.001	3	3
UCEC	PKC-delta_pS664 →	-0.088	-1.405	.018	.043	3	3
UCEC	4E-BP1 →	+0.366	+3.199	<.001	<.001	3	3
BLCA	Chk2_pT68 →	+0.216	+2.820	.006	.035	3	2
BLCA	4E-BP1_pT70 →	+0.215	+2.845	.008	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

ATM by KANK4 expression — COAD

Explore this box plot interactively →