KANK1

Across TCGA pan-cancer cohorts, KANK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KANK1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KANK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KANK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where KANK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.791	0.427	.001	49	view →
LUAD	OS	Median	All	1.000	0.767	.004	43	view →
CCRCC	DFS	Quartile	II,III,IV	0.972	0.077	.024	5	view →
PDAC	OS	Quartile	II,III,IV	0.212	0.515	.015	5	view →
GBM	OS	Tertile	All	0.671	0.465	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KANK1–HNSC (DFS)

Open the HNSC breakdown →