KANK1

Across TCGA patient cohorts, KANK1 mutation is significantly associated with the RNA expression of many other genes, with 6,637 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANK1-associated genes across cancer lineages are RNU6-898P, AP1S3, and TMEM69. Each is linked with KANK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KANK1-to-partner and partner-to-KANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-898P grouped by KANK1-low versus KANK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANK1→partner) and Y-score (partner→KANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-898P →	+0.162	+3.106	.005	.009	3	3
UCEC	AP1S3 →	+0.488	+2.222	<.001	<.001	3	3
UCEC	TMEM69 →	+0.260	+1.906	.003	.001	3	3
UCEC	RBBP4 →	+0.470	+1.351	<.001	<.001	3	3
UCEC	BOLA3 →	+0.305	+1.664	<.001	<.001	3	3
STAD	MTHFD2L →	+0.454	+3.334	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,637 associations by consensus.

RNU6-898P by KANK1 expression — BLCA

Explore this box plot interactively →