KANK1

Across TCGA cell cohorts, KANK1 mutation is significantly associated with the RNA expression of many other genes, with 1,268 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KANK1-associated genes across cancer lineages are TBC1D28, CPO, and COQ3. Each is linked with KANK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KANK1-to-partner and partner-to-KANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D28 grouped by KANK1-low versus KANK1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANK1→partner) and Y-score (partner→KANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TBC1D28 →	+0.036	+4.050	<.001	.002	3	2
BLOOD_Leukemia	CPO →	+0.054	+3.832	.005	.003	3	2
LARGE_INTESTINE	COQ3 →	+0.736	+3.321	<.001	.003	3	2
LARGE_INTESTINE	ATP5F1A →	+0.953	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	CXXC1 →	+0.976	+3.321	<.001	.003	3	2
LARGE_INTESTINE	SKA1 →	+0.748	+2.526	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,268 associations by consensus.

TBC1D28 by KANK1 expression — URINARY_TRACT

Explore this box plot interactively →