JUP

Across TCGA pan-cancer cohorts, JUP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated JUP data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher JUP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated JUP expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

COAD, LUAD, and GBM are the cancer types where JUP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.888	.023	48	view →
LUAD	DFS	Quartile	II,III,IV	0.158	0.866	.003	21	view →
GBM	DFS	Median	All	0.482	0.268	.002	12	view →
HNSC	DFS	Tertile	II,III,IV	0.991	0.864	.006	11	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	9	view →
LSCC	DFS	Median	II,III,IV	0.963	0.867	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

JUP–COAD (DFS)

Open the COAD breakdown →