JUP

Across TCGA patient cohorts, JUP protein abundance is significantly associated with the RNA expression of many other genes, with 19,637 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible JUP-associated genes across cancer lineages are ARHGEF6, FLI1, and ZNF385D. Each is linked with JUP in more than 6 cancer types. Because this analysis shows association rather than direction, both JUP-to-partner and partner-to-JUP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JUP versus ARHGEF6 in HNSC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JUP→partner) and Y-score (partner→JUP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGEF6 →	-0.760	-0.538	<.001	.001	3	7
OV	FLI1 →	-0.636	-0.532	<.001	<.001	3	7
UCEC	ZNF385D →	-0.621	-0.308	.006	.002	3	7
LSCC	IL16 →	-0.738	-0.759	<.001	<.001	3	7
LUAD	CYSLTR1 →	-0.807	-0.407	<.001	<.001	3	7
LSCC	CR1 →	-0.788	-0.967	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,637 associations by consensus.

JUP vs ARHGEF6 — HNSC

Explore this scatter interactively →