JUP

Across TCGA patient cohorts, JUP mutation is significantly associated with the RNA expression of many other genes, with 3,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JUP-associated genes across cancer lineages are TLE6, NPM3, and SMU1. Each is linked with JUP in more than 2 cancer types. Because this analysis shows association rather than direction, both JUP-to-partner and partner-to-JUP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE6 grouped by JUP-low versus JUP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JUP→partner) and Y-score (partner→JUP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLE6 →	+0.555	+3.614	.001	.001	3	3
COAD	NPM3 →	+0.649	+3.348	.002	.004	3	3
UCEC	SMU1 →	+0.335	+2.016	.001	.001	3	3
UCEC	ZWINT →	+0.659	+2.403	<.001	<.001	3	3
UCEC	EXOSC9 →	+0.401	+1.968	.001	<.001	3	3
UCEC	ECHS1 →	+0.363	+4.054	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,600 associations by consensus.

TLE6 by JUP expression — COAD

Explore this box plot interactively →