JUP

Across TCGA patient cohorts, JUP mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JUP-associated genes across cancer lineages are ERK2, MEK1, and ATM. Each is linked with JUP in more than 2 cancer types. Because this analysis shows association rather than direction, both JUP-to-partner and partner-to-JUP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by JUP-low versus JUP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JUP→partner) and Y-score (partner→JUP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.140	+1.700	.022	.040	3	3
UCEC	MEK1 →	+0.365	+4.169	.001	<.001	3	3
UCEC	ATM →	-0.584	-2.169	<.001	.003	3	3
UCEC	eIF4E →	+0.165	+2.820	.014	.001	3	2
UCEC	eIF4G →	+0.275	+3.700	.005	.001	3	2
UCEC	INPP4B →	-0.210	-2.169	.042	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by JUP expression — UCEC

Explore this box plot interactively →