JUP

Across TCGA cell cohorts, JUP mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JUP-associated genes across cancer lineages are PRSS58, OR2A4, and OR5B21. Each is linked with JUP in more than 1 cancer types. Because this analysis shows association rather than direction, both JUP-to-partner and partner-to-JUP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by JUP-low versus JUP-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JUP→partner) and Y-score (partner→JUP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR2A4 →	+0.067	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5B21 →	+0.064	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.014	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	SPATS1 →	+0.812	+4.714	<.001	.002	3	1
BLOOD_Leukemia	SAA2 →	+0.437	+3.273	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PRSS58 by JUP expression — PANCREAS

Explore this box plot interactively →