Across TCGA patient cohorts, JRKL mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JRKL-associated genes across cancer lineages are GAPDH, MEK1, and Shc_pY317. Each is linked with JRKL in more than 1 cancer types. Because this analysis shows association rather than direction, both JRKL-to-partner and partner-to-JRKL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JRKL→partner) and Y-score (partner→JRKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.403	+2.115	.018	.016	3	2
UCEC	MEK1 →	+0.394	+3.169	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.200	-2.058	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.575	+1.777	.002	.002	3	2
UCEC	14-3-3_beta →	-0.074	-2.195	.021	.009	3	1
UCEC	EGFR_pY1068 →	-0.264	-2.058	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

JRKL survival (RNA) · tumor vs normal (RNA) · all JRKL data types