JPH3

Across TCGA patient cohorts, JPH3 mutation is significantly associated with the RNA expression of many other genes, with 2,891 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JPH3-associated genes across cancer lineages are EMC7, MRPS18C, and NDUFAF2. Each is linked with JPH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both JPH3-to-partner and partner-to-JPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC7 grouped by JPH3-low versus JPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JPH3→partner) and Y-score (partner→JPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMC7 →	+0.287	+1.692	.001	.003	3	4
UCEC	MRPS18C →	+0.286	+1.436	.001	.001	3	3
SKCM	NDUFAF2 →	+0.440	+2.097	.002	.003	3	3
UCEC	FAM204A →	+0.293	+1.617	.008	.005	3	3
SKCM	ZFYVE19 →	+0.388	+3.751	<.001	<.001	3	3
UCEC	EIF1AX →	+0.377	+2.534	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,891 associations by consensus.

EMC7 by JPH3 expression — UCEC

Explore this box plot interactively →