JPH3

Across TCGA patient cohorts, JPH3 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JPH3-associated genes across cancer lineages are PKC-b-II_pS660, c-Met_pY1235, and PDCD4. Each is linked with JPH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both JPH3-to-partner and partner-to-JPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by JPH3-low versus JPH3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JPH3→partner) and Y-score (partner→JPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.316	-3.000	.019	.034	3	3
COAD	c-Met_pY1235 →	+0.081	+2.264	.035	.005	3	3
UCEC	PDCD4 →	-0.424	-1.906	.002	.014	3	2
UCEC	PRDX1 →	+0.165	+1.874	.006	.002	3	2
UCEC	Rad50 →	-0.175	-1.893	.014	.014	3	2
UCEC	Stathmin →	+0.116	+1.611	.004	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PKC-b-II_pS660 by JPH3 expression — COAD

Explore this box plot interactively →