JPH2

Across TCGA cell cohorts, JPH2 mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JPH2-associated genes across cancer lineages are GIMD1, ZC3H10, and SLCO1C1. Each is linked with JPH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JPH2-to-partner and partner-to-JPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMD1 grouped by JPH2-low versus JPH2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JPH2→partner) and Y-score (partner→JPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GIMD1 →	+0.030	+3.817	<.001	.004	3	2
LARGE_INTESTINE	ZC3H10 →	+0.343	+2.386	.008	.007	3	2
LARGE_INTESTINE	SLCO1C1 →	+0.305	+1.936	<.001	.009	3	2
BLOOD_Lymphoma	ACER1 →	+0.042	+3.795	.003	.004	3	2
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	2
LARGE_INTESTINE	MSH4 →	+0.252	+3.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

GIMD1 by JPH2 expression — LUNG_SCLC

Explore this box plot interactively →