JPH1

Across TCGA pan-cancer cohorts, JPH1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of JPH1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where JPH1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types JPH1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where JPH1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JPH1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.480	<.001	8	view →
HNSC	All	II,III,IV	−0.851	<.001	6	view →
LUAD	Male	All	−0.298	<.001	4	view →
LSCC	All	All	+0.129	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

JPH1–COAD

Open the COAD breakdown →