JPH1

Across TCGA patient cohorts, JPH1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JPH1-associated genes across cancer lineages are Shc_pY317, STAT3_pY705, and TFRC. Each is linked with JPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both JPH1-to-partner and partner-to-JPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by JPH1-low versus JPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JPH1→partner) and Y-score (partner→JPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.113	-1.906	.023	.015	3	3
UCEC	STAT3_pY705 →	-0.342	-1.916	<.001	.004	3	3
UCEC	TFRC →	+0.426	+1.807	.014	.024	3	3
UCEC	4E-BP1 →	+0.289	+2.936	.001	<.001	3	3
UCEC	MEK1 →	+0.371	+2.392	.002	<.001	3	2
UCEC	14-3-3_beta →	-0.080	-2.195	.016	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Shc_pY317 by JPH1 expression — UCEC

Explore this box plot interactively →