JOSD1

Across TCGA patient cohorts, JOSD1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JOSD1-associated genes across cancer lineages are mTOR_pS2448, VHL, and 14-3-3_beta. Each is linked with JOSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both JOSD1-to-partner and partner-to-JOSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by JOSD1-low versus JOSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JOSD1→partner) and Y-score (partner→JOSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.215	-2.986	.004	.035	3	2
UCEC	VHL →	-1.122	-2.321	<.001	.034	3	2
UCEC	14-3-3_beta →	-0.114	-3.143	.024	.018	3	1
UCEC	EGFR_pY1068 →	-0.300	-3.459	.017	.005	3	1
UCEC	A-Raf_pS299 →	-0.187	-3.000	.001	.036	3	1
UCEC	INPP4B →	-0.392	-2.999	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by JOSD1 expression — UCEC

Explore this box plot interactively →