JMY

Across TCGA patient cohorts, JMY mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JMY-associated genes across cancer lineages are MSH2, MSH6, and ATM. Each is linked with JMY in more than 1 cancer types. Because this analysis shows association rather than direction, both JMY-to-partner and partner-to-JMY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by JMY-low versus JMY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMY→partner) and Y-score (partner→JMY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.300	-3.366	<.001	<.001	3	2
UCEC	MSH6 →	-0.333	-1.652	.001	.010	3	2
UCEC	ATM →	-0.503	-3.986	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.492	+1.415	.004	.010	3	2
UCEC	14-3-3_beta →	-0.100	-3.880	.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.253	-1.643	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MSH2 by JMY expression — UCEC

Explore this box plot interactively →