JMJD7

Across TCGA pan-cancer cohorts, JMJD7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of JMJD7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where JMJD7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types JMJD7 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where JMJD7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JMJD7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.282	<.001	10	view →
COAD	Female	II,III,IV	+0.294	<.001	8	view →
KIRC	All	All	+0.078	.001	8	view →
READ	All	II,III,IV	+0.440	.004	6	view →
LUSC	Male	All	+0.456	<.001	4	view →
UCEC	All	All	+0.170	.010	4	view →
THCA	Female	All	−0.138	.001	4	view →
CHOL	All	All	+0.407	.001	2	view →
KICH	All	II,III,IV	+0.242	.018	2	view →
LIHC	All	All	+0.081	.007	2	view →
LUAD	Female	II,III,IV	−0.204	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

JMJD7–HNSC

Open the HNSC breakdown →