JMJD6

Across TCGA patient cohorts, JMJD6 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JMJD6-associated genes across cancer lineages are A-Raf_pS299, Acetyl-a-Tubulin-Lys40, and EGFR_pY1173. Each is linked with JMJD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD6-to-partner and partner-to-JMJD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by JMJD6-low versus JMJD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD6→partner) and Y-score (partner→JMJD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.106	-2.459	.026	.019	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.516	+2.469	.011	.010	3	2
UCEC	EGFR_pY1173 →	+0.076	+2.999	.018	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.117	-1.700	.019	.040	3	1
UCEC	MAPK_pT202_Y204 →	-0.599	-3.700	.001	.001	3	1
UCEC	MEK1_p_S217_S221 →	-0.266	-2.584	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

A-Raf_pS299 by JMJD6 expression — UCEC

Explore this box plot interactively →