JMJD6

Across TCGA cell cohorts, JMJD6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,681 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible JMJD6-associated GO terms across cancer lineages are Negative regulation of protein homooligomerization, Regulation of protein homooligomerization, and Negative regulation of RIG-I signaling pathway. Each is linked with JMJD6 in more than 16 cancer types. Because this analysis shows association rather than direction, both JMJD6-to-partner and partner-to-JMJD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein homooligomerization grouped by JMJD6-low versus JMJD6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD6→partner) and Y-score (partner→JMJD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of protein homooligomerization →	+0.244	+0.905	<.001	<.001	3	17
BONE	Regulation of protein homooligomerization →	+0.344	+1.035	<.001	<.001	3	13
SOFT_TISSUE	Negative regulation of RIG-I signaling pathway →	+0.087	+0.619	.001	<.001	3	11
LIVER	Protein-RNA covalent cross-linking repair →	+0.079	+0.583	.009	.006	3	10
BLOOD_Myeloma	Negative regulation of protein oligomerization →	+0.175	+1.036	.003	.003	2	10
PANCREAS	Regulation of transcription by RNA polymerase III →	+0.060	+0.394	.003	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,681 associations by consensus.

Negative regulation of protein homooligomerization by JMJD6 expression — BONE

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