JMJD6

Across TCGA cell cohorts, JMJD6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible JMJD6-associated genes across cancer lineages are OR2AJ1, LMX1A, and HES3. Each is linked with JMJD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD6-to-partner and partner-to-JMJD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by JMJD6-low versus JMJD6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD6→partner) and Y-score (partner→JMJD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.034	+5.452	<.001	<.001	3	2
BLOOD_Lymphoma	LMX1A →	+0.040	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	HES3 →	+0.125	+4.523	<.001	.004	3	1
BLOOD_Leukemia	LCE2A →	+0.053	+4.969	<.001	.003	3	1
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
SKIN	CLRN2 →	+0.025	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR2AJ1 by JMJD6 expression — BLOOD_Lymphoma

Explore this box plot interactively →