JMJD4

Across TCGA patient cohorts, JMJD4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JMJD4-associated genes across cancer lineages are JNK2, Annexin-1, and Caspase-7-cleavedD198. Each is linked with JMJD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD4-to-partner and partner-to-JMJD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by JMJD4-low versus JMJD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD4→partner) and Y-score (partner→JMJD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.163	+2.834	.047	.034	3	2
UCEC	Annexin-1 →	+0.440	+3.019	.043	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.688	+1.807	.004	.027	3	2
UCEC	14-3-3_beta →	-0.100	-2.973	.015	.035	3	1
UCEC	EGFR_pY1068 →	-0.203	-1.807	.049	.027	3	1
UCEC	eIF4E →	+0.202	+3.321	.020	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK2 by JMJD4 expression — UCEC

Explore this box plot interactively →