JMJD4

Across TCGA cell cohorts, JMJD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,000 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible JMJD4-associated GO terms across cancer lineages are Regulation of translational termination, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, and tRNA transcription. Each is linked with JMJD4 in more than 16 cancer types. Because this analysis shows association rather than direction, both JMJD4-to-partner and partner-to-JMJD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational termination grouped by JMJD4-low versus JMJD4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD4→partner) and Y-score (partner→JMJD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of translational termination →	+0.156	+0.829	<.001	<.001	3	17
STOMACH	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.150	+0.696	<.001	.004	3	14
BONE	tRNA transcription →	+0.139	+0.937	.002	<.001	3	13
STOMACH	Establishment of RNA localization →	+0.091	+0.778	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.153	+0.669	.004	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase I →	+0.090	+0.629	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,000 associations by consensus.

Regulation of translational termination by JMJD4 expression — LUNG_NSCLC_LUSC

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