JMJD4

Across TCGA cell cohorts, JMJD4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JMJD4-associated genes across cancer lineages are IFNA2, PRAMEF11, and KRTAP20-2. Each is linked with JMJD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD4-to-partner and partner-to-JMJD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA2 grouped by JMJD4-low versus JMJD4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD4→partner) and Y-score (partner→JMJD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IFNA2 →	+0.022	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF11 →	+0.026	+5.029	<.001	.006	3	1
OVARY	KRTAP20-2 →	+0.096	+5.196	<.001	.005	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	RAX2 →	+0.075	+3.196	<.001	.007	3	1
LARGE_INTESTINE	ZNF679 →	+0.021	+3.347	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IFNA2 by JMJD4 expression — LUNG_SCLC

Explore this box plot interactively →