JMJD1C

Across TCGA patient cohorts, JMJD1C mutation is significantly associated with the RNA expression of many other genes, with 4,524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JMJD1C-associated genes across cancer lineages are FAXDC2, KNL1, and RRM2. Each is linked with JMJD1C in more than 4 cancer types. Because this analysis shows association rather than direction, both JMJD1C-to-partner and partner-to-JMJD1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAXDC2 grouped by JMJD1C-low versus JMJD1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD1C→partner) and Y-score (partner→JMJD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAXDC2 →	-0.609	-1.647	<.001	<.001	3	5
UCEC	KNL1 →	+0.399	+1.838	.001	<.001	3	5
UCEC	RRM2 →	+0.576	+1.523	<.001	<.001	3	4
UCEC	TYMS →	+0.567	+1.289	<.001	<.001	3	4
LUAD	UBE2T →	+1.035	+3.596	<.001	.001	3	4
UCEC	TMEM269 →	+0.124	+1.739	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,524 associations by consensus.

FAXDC2 by JMJD1C expression — UCEC

Explore this box plot interactively →