JKAMP

Across TCGA patient cohorts, JKAMP mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JKAMP-associated genes across cancer lineages are STAT3_pY705, eIF4E, and eIF4G. Each is linked with JKAMP in more than 1 cancer types. Because this analysis shows association rather than direction, both JKAMP-to-partner and partner-to-JKAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by JKAMP-low versus JKAMP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JKAMP→partner) and Y-score (partner→JKAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.387	-2.797	<.001	.003	3	2
UCEC	eIF4E →	+0.219	+3.700	.009	.001	3	1
UCEC	eIF4G →	+0.252	+3.169	.044	.019	3	1
UCEC	ACC1 →	+0.372	+3.013	.011	.018	3	1
UCEC	JNK2 →	+0.175	+1.906	.029	.016	3	1
UCEC	Ku80 →	+0.229	+1.498	.016	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

STAT3_pY705 by JKAMP expression — UCEC

Explore this box plot interactively →