JHY

Across TCGA patient cohorts, JHY mutation is significantly associated with the RNA expression of many other genes, with 5,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JHY-associated genes across cancer lineages are DLAT, NOLC1, and POLQ. Each is linked with JHY in more than 3 cancer types. Because this analysis shows association rather than direction, both JHY-to-partner and partner-to-JHY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLAT grouped by JHY-low versus JHY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JHY→partner) and Y-score (partner→JHY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DLAT →	+0.505	+1.958	<.001	.002	3	4
UCEC	NOLC1 →	+0.507	+1.572	<.001	<.001	3	4
UCEC	POLQ →	+0.442	+2.040	<.001	<.001	3	4
UCEC	AXIN1 →	+0.412	+1.917	<.001	<.001	3	4
UCEC	BAG3 →	+0.631	+2.129	<.001	<.001	3	3
UCEC	DDAH1 →	+0.513	+2.091	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,004 associations by consensus.

DLAT by JHY expression — UCEC

Explore this box plot interactively →