JHY

Across TCGA patient cohorts, JHY mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JHY-associated genes across cancer lineages are Caveolin-1, FoxM1, and Cyclin-E2. Each is linked with JHY in more than 4 cancer types. Because this analysis shows association rather than direction, both JHY-to-partner and partner-to-JHY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by JHY-low versus JHY-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JHY→partner) and Y-score (partner→JHY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Caveolin-1 →	-1.115	-3.000	<.001	.034	3	5
UCEC	FoxM1 →	+0.149	+1.115	.048	.026	3	3
UCEC	Cyclin-E2 →	+0.107	+1.415	.029	.040	3	3
UCEC	eIF4E →	+0.202	+2.415	<.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.085	-1.767	.019	.001	3	2
UCEC	ACC1 →	+0.304	+1.485	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Caveolin-1 by JHY expression — SKCM

Explore this box plot interactively →