JDP2

Across TCGA patient cohorts, JDP2 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JDP2-associated genes across cancer lineages are TTTY4B, MIR6744, and DPP10-AS1. Each is linked with JDP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JDP2-to-partner and partner-to-JDP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY4B grouped by JDP2-low versus JDP2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JDP2→partner) and Y-score (partner→JDP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TTTY4B →	+0.014	+7.924	<.001	.008	3	1
LUSC	MIR6744 →	+0.483	+7.924	<.001	.008	3	1
CESC	DPP10-AS1 →	+0.989	+4.503	<.001	.005	3	1
CESC	PIEZO1P2 →	+0.018	+4.816	.009	.003	3	1
CESC	RPL30P12 →	+0.129	+5.196	<.001	.001	3	1
CESC	RN7SL266P →	+0.095	+6.584	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

TTTY4B by JDP2 expression — LUSC

Explore this box plot interactively →